Frank Harrison was born in Oxford on 8 July 1978. He took up the piano at 11, and began playing gigs when he was 15. In 1994 he won the soloist award in the Daily Telegraph Young Jazz Competition, and in 1996 placed second in Young Jazz Musician Of The Year.

After taking up a scholarship at Berklee School Of Music, Boston, he returned to England and joined Gilad Atzmon's band. In 2000 they started the Orient House Ensemble, with whom Frank has recorded four albums on Enja Records, including BBC Jazz Album Of The Year 2003, "Exile". The band regularly tours Europe, playing at major Jazz and World music festivals. Frank has also performed with Peter KIng, Julian Arguelles, Julian Siegal, Don Weller, Alan Barnes, John Etheridge, Louis Stewart and Ian Ballamy.